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TATA box binding proteins

The regulation of transcription initiation in eukaryotes is most thoroughly investigated with genes translated by RNA polymerase II. The process starts by recognition of a stretch of DNA containing a TATA sequence by a general initiation factor TFII (A - J). This involves a TATA box binding protein, too. The ternary complex formed from DNA/TBP/TFII binds more factors as well as the polymerase and thus forms the preinitiation complex (PIC).
TATA box binding proteins could be crystallized on their own or bound to DNA or even as ternary complex. The structures of these crystals were elucidated by x-ray diffraction.

1tgh.gif 1ytb.gif   1ytf1.gif 1vol1.gif
homo yeast TBP yeast Arabidopsis
- - TFII A   yeast B   homo
Adenovirus synthetic DNA Cyc1 Adenovirus
1tgh 1ytb PDB-ID 1ytf 1vol

The properties of a ternary complex shall be shown here with the TBP from Arabidopsis thaliana. Use your mouse to click here for the Jsmol version. (The old Chime version - only for coputer of 2000)



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